hrp0097p2-74 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

A recessive heterozygous mutation in ABCC8 gene as the cause of severe congenital hyperinsulinism: a case report

Scheidemantel Aline , de Carvalho Kraemer Gabriela , Nesi-França Suzana , Ângela Ramires De Carvalho Julienne , Marcolla Bordin Pazzini Luiza , Eduardo Cruvinel Pinto Luís , Junqueira Soares Gabriel , De Lacerda Luiz , Marques Pereira Rosana , Cardoso-Demartini Adriane

Case Report: A preterm boy was born at 35 weeks gestational age by cesarean section due to fetal macrossomia and polyhydramnios, weight 4980g (4.3 SDS, Intergrowth 21st), length 53cm (3.1 SDS), 1-min-Apgar 2. He needed resuscitation after birth, and his glycemia was 20 mg/dL. At the Neonatal Intensive Care Unit (NICU), he presented with severe hypoglycemia (10mg/dL) and required intravenous glucose infusion rate (GIR) 10mg/kg/min that increased progressively u...